AUTOLOGOUS BIOLOGICS

ActiGraft+ Whole blood clot

An autologous, point-of-care wound management system by Legacy Medical Consultants. A 20 mL venipuncture becomes a whole-blood-clot wound dressing in 5–10 minutes at the point of care — no centrifuge, no donor tissue, no additives.

Schedule a consultation → Common questions
ActiGraft+ whole blood clot dressing applied to wound
The Procedure

Point-of-care, in 5 minutes of coagulation.

From blood draw to applied dressing — a streamlined, centrifuge-free workflow any clinical setting can execute.

Step 01

Blood draw

20 mL (20 cc) of autologous blood drawn from the patient directly into anticoagulant tubes. No centrifuge, no donor tissue.

Step 02

Prepare & mix

20 mL is drawn from the tubes into the syringe, injected into the sterile mold, and mixed for 15–30 seconds.

Step 03

Clot formation

Blood coagulates at point of care in 5–10 minutes (+5 min on blood thinners). Blood can be drawn and stored up to 24 hours prior for scheduling flexibility.

Step 04

Application

Tyvek backing removed, gel loosened and transferred, excess fluid drained. The gel is sized and applied directly to the wound.

Step 05

Secure & dress

Steri-strips secure the autologous gel, primary dressing applied. Single 28 cm² application covers wounds up to 56 cm².

ActiGraft advantages

Natural healing, activated at the point of care.

Concentrated growth factors, cytokines, and fibrin delivered directly to the wound bed — from the patient's own blood.

Clinical outcomes (DFU RCT)

173% healing advantage

173% more patients healed in the intervention arm vs. standard of care (ITT population, odds ratio 2.73) in a randomized controlled trial of diabetic foot ulcers.

Workflow

Streamlined procedure

No centrifuge, 5–10 minute coagulation, and the flexibility to draw and store blood up to 24 hours prior. All sterile tools and materials included in a single kit — no additional supplies required.

Autologous

Natural healing, your blood

Created from the patient's own peripheral whole blood — even in the presence of blood thinners. Immediately available at point of care. No donor tissue, no wait. Suitable for patients with religious or allogeneic sensitivities.

Reference: Snyder R, Nouvong A, Ulloa J, et al. Efficacy and safety of autologous whole blood clot in diabetic foot ulcers: a randomized controlled trial. Journal of Wound Care. Published online 30 Aug 2024. doi:10.12968/jowc.2024.0195

Coding, Coverage & Documentation

Coding, coverage, & documentation.

Everything billing and compliance teams need to support a clean HCPCS G0465 claim — drawn from Legacy Medical Consultants’ 2026 billing guide and Medicare NCD 270.3 guidance.

Coding & Coverage

HCPCS (diabetic)G0465 — PRP/blood-derived, diabetic
HCPCS (non-diabetic)G0460 — contractor priced
NCD270.3 — Blood-Derived Products
Coverage durationUp to 20 weeks; beyond: MAC + KX mod
Applicable POS11, 12, 19, 22, 31, 49
Clot size28 cm² — covers wounds up to 56 cm²
Storage41–86°F room temp
ManufacturerLegacy Medical Consultants

ICD-10 required pairing

Claims reporting G0465 must include both:

  • Diabetes mellitus codeE10.621, E11.621, E08.621 (foot ulcer) or the corresponding skin-ulcer codes
  • Chronic ulcer codeL97.xxx (foot/leg) or L98.xxx (other anatomic sites) matching the wound location

Medical-necessity documentation

Legacy Medical’s chart-note checklist aligned with NCD 270.3:

  • Patient & servicePatient name and date(s) of service
  • HPIChronic wound type, duration, prior non-responding care
  • ICD-10 codesDiabetes + chronic ulcer (both required)
  • RationaleChronic non-healing nature, failure of prior therapy
  • Wound documentationMeasurements (before & after), tunneling/undermining, drainage, debridement history, wound-bed description
  • Clinical contextComorbidities, wound barriers (neuropathy, arterial, osteomyelitis), failure-of-response detail

Extended-coverage rule: Beyond 20 weeks, applications require modifier KX with physician documentation of continued ulcer progress and rationale for continued therapy.

Coverage for non-diabetic chronic ulcers (G0460) is determined by local MACs. Covered places of service include POS 11 (office), 19/22 (outpatient hospital), 49 (independent clinic), 12 (home), and 31 (SNF Part B). ActiGraft is contraindicated in ulcers due to malignancy or with active clinically diagnosed infection. Coverage and payment depend on payer policy and medical necessity; consult your MAC or the ActiGraft Coverage Support Program for case-specific guidance.

Common questions

What to know about ActiGraft+.

Who can use ActiGraft+? +
ActiGraft+ is indicated for point-of-care preparation of whole blood clot (WBC) from a small sample of the patient's own peripheral blood, topically applied for management of exuding cutaneous ulcers — leg ulcers, pressure ulcers, diabetic ulcers, and mechanically or surgically-debrided ulcers. Under Medicare NCD 270.3, coverage is established for chronic non-healing diabetic ulcers via HCPCS G0465; coverage for other non-healing ulcers is determined by local MACs under G0460.

ActiGraft+ is contraindicated in ulcers due to malignancy or ulcers with active clinically diagnosed infection.
How long does prep take? +
Coagulation takes 5–10 minutes at the point of care (up to 5 minutes longer if the patient is on blood thinners). The streamlined process requires no centrifuge — 20 mL of blood is drawn into anticoagulant tubes, transferred to the mold, mixed for 15–30 seconds, and the resulting whole blood clot is applied directly to the wound bed. Blood can also be drawn and stored up to 24 hours prior to the procedure for scheduling flexibility.
What's in an ActiGraft kit? +
The kit contains all sterile tools and materials required to perform a wound care procedure — including blood draw equipment, coagulation tools and materials, primary and secondary dressing equipment, procedure tray, and sterile sheet. Everything needed for a complete treatment is contained in a single, convenient kit with no additional supplies required.
Why partner with Albacete MedDev? +
With Albacete MedDev, ActiGraft is delivered as a partnership, not just a product. Our team provides education across coverage, reimbursement, training, and implementation. You gain access to our full compliance infrastructure, documentation support, and billing guidance — ensuring your practice captures appropriate reimbursement while maintaining audit-ready records.
Ready when you are

Add ActiGraft+ to your practice.

A 30-minute consultation to walk through clinical training, reimbursement pathways, and implementation.

Schedule a consultation → Explore the portfolio